REMARKABLE PROTECTIVE EFFECTS OF NRF2-MEDIATED ANTIOXIDANT ENZYMES AND TISSUE SPECIFICITY IN DIFFERENT SKELETAL MUSCLES OF DAURIAN GROUND SQUIRRELS OVER THE TORPOR-AROUSAL CYCLE

Hibernating mammals experience conditions of extreme oxidative stress, such as fasting, muscle disuse, and repeated hypoxic ischemia-reperfusion, during the torpor-arousal cycle.Despite this, they experience little oxidative injury and are thus an interesting model of anti-oxidative damage.Thus, in the current study, we explored the levels and unde

The following article, by A.A.Manten Drain Maintenance of the Netherlands, was published in KOERS in March and April 1959 (Volume XXVI, numbers 9 & 10) as part of a centenary debate on evolution and Darwinism.He deals with the fact that the Bible does not have the intention of teaching scientific fact - and this leads him to the point that Interpre

We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels.The primary function of sodium channels is to allow the propagation of action potentials.Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightly constrained Showerproof J

Tobacco smoking is recognized as a major preventable cause of disease worldwide and is linked to 6 million deaths annually, 30% of which are due to cancer.The negative health consequences of smoking currently represent one of the greatest public health challenges.Secondhand smoke, declared carcinogenic by the International Agency for Research on Ca

Two hundred and thirty four actinobacteria strains were isolated from Argentinian and Peruvian soil in order to evaluate the antimicrobial activity against multidrug resistant bacteria On the basis of their antagonist activity against methicillin-resistant Staphylococcus aureus (MRSA) and two vancomycin-resistant Enterococcus (EVR-Van A and EVR Van